Cancer cachexia: an atlas of 52,000 patients to anticipate risk
A study on longitudinal clinical and genomic data links weight loss episodes to prognosis, blood tests, and tumour mutations.
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Health, medicine, research and wellbeing
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Trust in science is high in the US, but internal divides weigh on public health
The Wellcome Global Monitor finds higher trust in science in the United States than the global average. However, religion, education and geography remain sharp fault lines.
Clinical models, code remains the weak link in reproducibility
A review of 3,967 studies finds that only 12.2% state they share code. For clinical predictive models, publishing alone is not enough.
WHO Pandemic Agreement: what the historic 2025 deal actually changes
The World Health Assembly adopted the first WHO Pandemic Agreement, focusing on prevention, equitable access to medical countermeasures, supply chains and preparedness.
Leqembi and early Alzheimer’s: why EMA changed its view after re-examination
After an initial negative opinion, EMA’s CHMP recommended Leqembi for a restricted group of people with early Alzheimer’s and a selected genetic profile.
Mpox: why WHO declared another international health emergency in August 2024
Rising cases in the Democratic Republic of the Congo and spread of clade Ib prompted WHO to declare a new international health emergency.
Wegovy and cardiovascular risk: why the FDA decision changed the obesity-drug debate
In March 2024 the FDA expanded Wegovy’s indication to reduce cardiovascular death, heart attack and stroke in adults with cardiovascular disease and obesity or overweight.
Casgevy, the first FDA-approved CRISPR therapy, opens a new era for genetic medicine
Casgevy’s approval for sickle cell disease moved CRISPR from laboratory technology to regulated medicine. Here is how it works and what challenges remain.